Endometrial Cancer Metastasis Responds to THC

“Add Uterine Cancer to the growing list of cancers that cannabinoids appear to affect. THC both inhibits cell migration (metastasis) of cancer cells and regulates tumor growth via both the CB1R and CB2R.”

- Dr. David Hepburn

Abstract:

Limited therapeutic interventions are clinically available for treating aggressive endometrial cancer (EC). Therefore, effective therapies are urgently required. Therefore, the present study investigated the role of ∆9-tetrahydrocannabinol (THC), which is reported to impact proliferative and migratory activities during impairment of cancer progression. In the present study, cell migration in response to THC was measured using transwell assays.

Read full article here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950514/

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Dr. Dave Hepburn website: https://doctordavidhepburn.com

Does Cannabis Significantly increase the risk of Traffic Accidents. No.

“The increased crash risk associated with THC-positive drivers in a large number of (meta-analysis) culpability studies show. Risk of being involved in or cause of traffic accident while using alcohol and many prescription drugs are not low.”

-       Dr. David Hepburn

Abstract:

Culpability studies, a common study design in the cannabis crash risk literature, typically report odds-ratios (OR) indicating the raised risks of a culpable accident. This parameter is of unclear policy relevance, and is frequently misinterpreted as an estimate of the increased crash risk, a practice that introduces a substantial "interpretational bias".

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30468948

VIsitDr. Dave Hepburn website: https://doctordavidhepburn.com

CBD May Inhibit the Pain Reducing Effects of THC

“Which is why it is important to know how cannabis acts as medicine. Don’t try to treat yourself with ditch weed, see a knowledgeable doctor. CBD acts as a NAM (negative allosteric modulator) to THC. This is sometimes beneficial (decreasespsycho active effects and allows THC to work longer) and sometimes possibly detrimental, as in this study.”

- Dr. David Hepburn

Abstract:

Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development.

The decrease in THC's antinociceptive effects after repeated CBD exposure may be due to CBD-induced inhibition of THC metabolism, and/or antagonism of THC effects that emerge with repeated CBD treatment.

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30238130

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Dr. Dave Hepburn website: https://doctordavidhepburn.com

Stimulation of Cannabinoid Receptor Inhibits Gastric Acid Secretion

“CB1R agonism (which is what THC is) inhibits powerful gastric acid secretion (a culprit in acid reflux and ulcers) while enhancing protective mucin release.”

-    Dr. David Hepburn

Summary:

Thecurrentstudyaimed to evaluate the role of cannabinoid receptors in the regulation of gastric acid secretion and oxidative stress in gastric mucosa. To fulfill this aim, gastric acid secretion stimulated with histamine (5 mg/kg, subcutaneous [SC]), 2-deoxy- d-glucose (D-G) (200 mg/kg, intravenous) or -carbachol (4 μg/kg, SC) in the 4-hour pylorus-ligated rats.

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30381869

Dr. David Hepburn website: https://doctordavidhepburn.com

THC Weakens Brain Connections Responsible for Pain

“In a fascinating study on humans, THC appears to disconnect areas of the brain responsible for feeling pain. It acts as a cognitive-emotional modulator.  Less pain and less unpleasantness associated with the pain. Very exciting research.”

-   Dr. David Hepburn

THC significantly reduced patients’ pain compared to placebo. THC-induced analgesia was correlated with a reduction in functional connectivity between the anterior cingulate cortex (ACC) and the sensorimotor cortex.

Moreover, the degree of reduction was predictive of the response to THC.

Graph Theory Analysis of local measures demonstrated a reduction in network connectivity in areas involved in pain processing, and specifically in the dorsolateral prefrontal cortex (DLPFC), which were correlated with individual pain reduction.

Read full article here:

https://cdn.doctorsonly.co.il/2018/10/Cannabis-analgesia-in-chronic-neuropathic-pain-Neurology-2018.pdf

Dr. Dave Hepburn website: https://doctordavidhepburn.com

New Study: THC Reduces Neuropathic Pain - Dr. David Hepburn

Article recommend by Dr. Dave Hepburn:

Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity.

Abstract

OBJECTIVE: 

To characterize the functional brain changes involved in δ-9-tetrahydrocannabinol (THC) modulation of chronic neuropathic pain. 

METHODS: 

Fifteen patients with chronic radicular neuropathic pain participated in a randomized, double-blind, placebo-controlled trial employing a counterbalanced, within-subjects design. Pain assessments and functional resting state brain scans were performed at baseline and after sublingual THC administration. We examined functional connectivity of the anterior cingulate cortex (ACC) and pain-related network dynamics using graph theory measures. 

RESULTS: 

THC significantly reduced patients' pain compared to placebo. THC-induced analgesia was correlated with a reduction in functional connectivity between the anterior cingulate cortex (ACC) and the sensorimotor cortex. Moreover, the degree of reduction was predictive of the response to THC. Graph theory analyses of local measures demonstrated reduction in network connectivity in areas involved in pain processing, and specifically in the dorsolateral prefrontal cortex (DLPFC), which were correlated with individual pain reduction. 

CONCLUSION: 

These results suggest that the ACC and DLPFC, 2 major cognitive-emotional modulation areas, and their connections to somatosensory areas, are functionally involved in the analgesic effect of THC in chronic pain. This effect may therefore be mediated through induction of functional disconnection between regulatory high-order affective regions and the sensorimotor cortex. Moreover, baseline functional connectivity between these brain areas may serve as a predictor for the extent of pain relief induced by THC.

“Neuropathic pain, so difficult to control, is extremely common. This study is yet another feather in the THC cap. By interrupting one of the pain pathways contributing to neuropathic pain, sublingual THC joins CBD as potentially a useful pain treatment."

Dr. David Hepburn

To read the full article please visit:
https://www.ncbi.nlm.nih.gov/pubmed/30185448

Dr. Dave Hepburn website:
doctordavidhepburn.com

Cannabis leads to fewer bladder infections - Dr. David Hepburn

Article recommend by Dr. David Hepburn:

The Association Between Tetrahydrocannabinol and Lower Urinary Tract Symptoms Utilizing the National Health and Nutrition Examination Survey.

Abstract:

OBJECTIVE:

To further define the relationship between tetrahydrocannabinol (THC) and lower urinary tract symptoms (LUTS), specifically how THC use associates with the frequency of LUTS in young community-dwelling men in the United States. 

MATERIALS AND METHODS:

The National Health and Nutrition Examination Survey (NHANES) database was queried (2005-2008). Men ages 20-59 who completed the urinary and substance abuse questionnaires were included. The presence of LUTS was defined as having ≥2 of the following: nocturia (≥2), hesitancy, incomplete emptying, or incontinence. THC use was self-reported, and participants were considered regular smokers if they endorsed smoking at least once per month. Multivariable logistic regression was performed to analyze the relationship between THC and LUTS. 

RESULTS:

Among 3,037 men who met inclusion criteria, 14.4% (n=477) of subjects reported THC use. In multivariable analyses, adjusting for clinical variables, regular THC users remained significantly less likely to report LUTS (odds ratio of 0.55; CI 95% 0.408-0.751, p<0.01) compared to non-users. 

CONCLUSION:

Obesity, diabetes, and multiple co-morbidities are well-established risk factors for LUTS within the NHANES. Regular THC use, however, appears to be protective from LUTS in young community-dwelling men.

“Bladder infections are an extremely common concern. Should this extrapolate to all demographics, this would be very significant."

Dr. Dave Hepburn

To read the full article please visit:
https://www.ncbi.nlm.nih.gov/pubmed/30142408

Dr. Dave Hepburn website:

doctordavidhepburn.com