“In a fascinating study on humans, THC appears to disconnect areas of the brain responsible for feeling pain. It acts as a cognitive-emotional modulator. Less pain and less unpleasantness associated with the pain. Very exciting research.”
- Dr. David Hepburn
- Dr. David Hepburn
THC significantly reduced patients’ pain compared to placebo. THC-induced analgesia was correlated with a reduction in functional connectivity between the anterior cingulate cortex (ACC) and the sensorimotor cortex.
Moreover, the degree of reduction was predictive of the response to THC.
Graph Theory Analysis of local measures demonstrated a reduction in network connectivity in areas involved in pain processing, and specifically in the dorsolateral prefrontal cortex (DLPFC), which were correlated with individual pain reduction.
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