Early Life Stress and the ECS

Tuesday, 22 January 2019

“Levels of eCBs (AEA and 2AG) and the entire ECS, in fact, change in the hippocampus (memory) amygdala (fear) and PFC (executive) after early life stress. These continue in some of these regions into adulthood. Collectively, these data demonstrate that early life stress can alter the normative development (ontogeny) of the eCB system, resulting in a sustained deficit in function, particularly within the hippocampus, in adulthood.”
- Dr. David Hepburn 

Early-life stress modulates the development of cortico-limbic circuits and increases vulnerability to adult psychopathology. Given the important stress-buffering role of endocannabinoid (eCB) signaling, this is a comprehensive investigation of the developmental trajectory of the eCB system and the impact of exposure to early life stress induced by repeated maternal separation (MS; 3 h/day) from postnatal day 2 (PND2) to PND12.

Read full article here:



Dr. David Hepburn website: https://doctordavidhepburn.com


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