“Uveitis can lead to blindness. The inflammation associated with this not-uncommon condition may well be determined through CB2R agonism.”
- Dr. David Hepburn
Abstract:
Uveitis is inflammation of the uvea which consists of the iris, ciliary body and the choroid of the eye. Uveitis can lead to impaired vision and is responsible for 10% of all cases of blindness globally.
Usinganendotoxin-induced uveitis (EIU) rodent model, a previous data implicated the endogenous cannabinoid system (ECS) in the amelioration of many of the components of the inflammatory response.
Thisinvestigationteststhehypothesisthat the reduction in inflammatory mediators in the EIU model by the CB2 agonist, HU308, is associated with changes in ECS endogenous ligands as well as related lipids, prostaglandins (PGs), 2-acylglycerols, and lipoamines. Analysis of leukocytes and neutrophils, CB2 mRNA, and 26 lipids in the eye of WT mice after EIU induction and HU308 treatment were compared to the same analyses in the CB2knock-out (CB2 KO) mouse.
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