Endocannabinoids Worsen Heart Function After Heart Attack

Monday, 7 January 2019

“The ECS reacts to try to balance our inner milieu when that milieu is disturbed. Sometimes, as our body tries to help itself, it can end up doing some damage. Endocannabinoids do not cause heart attacks, of course, but they are releases in response to this major stressor.”
-   Dr. David Hepburn.

Intravenous administration of endocannabinoid 2-arachidonoylglycerol into wildtype C57BL6 mice induced a rapid increase of blood neutrophil and monocyte counts as measured by flow cytometry.

This effect was blunted when using cannabinoid receptor 2 knockout mice. In response to myocardial infarction induced in wildtype mice, the lipidomic analysis revealed significantly elevated plasma and cardiac levels of the endocannabinoid 2-arachidonoylglycerol 24 h after infarction, but no changes in anandamide, palmitoylethanolamide and oleoylethanolamide.

Read full article here:


Dr. Dave Hepburn website: https://doctordavidhepburn.com


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