“Which is why it is important to know how cannabis acts as medicine. Don’t try to treat yourself with ditch weed, see a knowledgeable doctor. CBD acts as a NAM (negative allosteric modulator) to THC. This is sometimes beneficial (decreasespsycho active effects and allows THC to work longer) and sometimes possibly detrimental, as in this study.”
- Dr. David Hepburn
Abstract:
Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development.
The decrease in THC's antinociceptive effects after repeated CBD exposure may be due to CBD-induced inhibition of THC metabolism, and/or antagonism of THC effects that emerge with repeated CBD treatment.
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