Cannabinoid 2 Receptors and Rheumatoid Arthritis

Friday, 11 January 2019

“A major raisond’etre for CB2 receptors (CB2R) are as immunomodulators (whereas CB1R has more of neuromodulatory reputation). Part of its life as an immune modulator regulating inflammation, an important and unfortunate component of many disease processes. CB2 activation decreases expression of pro-inflammatory cytokines, which in turn decreases bone destruction in joints affected by rheumatoid arthritis. In short, more and more evidence points to working with CB2 receptors as a means to decrease the destructive effects of inflammation.”
- Dr. David Hepburn


Cannabinoid receptor 2 (CB2) has been implicated as an important clinical regulator of inflammation and malignant osteolysis.

Here, its observed that CB2 expression was markedly higher in collagen-induced arthritis (CIA) mice synovium and bone tissues than in the non-inflamed synovium and bone tissues. The CB2 selective agonist (JWH133) but not an antagonist (SR144528) suppressed CIA in mice without toxic effects, as demonstrated by the decreased synovial hyperplasia, inflammatory responses, cartilage damage, and periarticular and systemic bone destruction.

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Dr. David Hepburn website:


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