CBD: Cheese Bacon Donuts

Wednesday, 2 January 2019

“With an increasing number of patients being prescribed CBD, it is often asked whether to take it on an empty stomach or with meals. PKPD studies show that taking it with a high fat meal increases the amount absorbed into the blood by over four times.”
-          Dr. David Hepburn



A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose, and to examine the effect of food on CBD PK parameters.


This trial assessed the safety, tolerability and PK of CBD oral solution in healthy adult volunteers, as well as the effect of food on CBD PK parameters.


The study consisted of three arms: single ascending dose (1500, 3000, 4500 or 6000 mg CBD [n = 6 per group]/placebo [n = 8; 2 per CBD dose group]), multiple dose (750 or 1500 mg CBD [n = 9 per group]/placebo [n = 6; 3 per CBD dose group] twice daily), and food effect (1500 mg CBD single dose [n = 12]). All subjects completed all trial arms and were analyzed as planned.

Read full article here:

Dr. David Hepburn website: https://doctordavidhepburn.com


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