THC For Fibromyalgia

“An exciting new study shows that THC, not CBD, is what raises the painters hold for those with FM. From only being able to tolerate 1 kg pressure on a hand muscle,  A SINGLE inhalation of THC allows patients to withstand normal 10kg of pressure without pain.”

- Dr. David Hepburn

Abstract:

This experimental trial shows the complex behavior of inhaled cannabinoids in chronic pain patients with just small analgesic responses after a single inhalation.

Further studies are needed to determine long-term treatment effects on spontaneous pain scores, THC-CBD interactions and the role of psychotropic symptoms on pain relief.

Read full article here:

https://journals.lww.com/pain/Abstract/publishahead/An_experimental_randomized_study_on_the_analgesic.98794.aspx

Visit 

Dr. Dave Hepburn website: https://doctordavidhepburn.com

Another GPR Affected by CBD

“Add GPR12 to the growing list of orphaned receptors (no known natural ligands) with which cannabis interacts. GPR12 may be involved in metastatic (spreading) cancer. Interest continues to grow in the role of the many types of GP Receptors in disease process ranging from Parkinson’s Disease to Inflammatory bowel disease to cancers.”

- Dr. David Hepburn

Abstract:

GPR12 is a constitutively active, Gs protein-coupled receptor that currently has no confirmed endogenous ligands. 

GPR12 may be involved in physiological processes such as maintenance of oocyte meiotic arrest and brain development, as well as pathological conditions such as metastatic cancer.

In this document, the potential effects of various classes of cannabinoids on GPR12 were tested using a cAMP accumulation assay. 

Data demonstrate that cannabidiol (CBD), a major non-psychoactive phytocannabinoid, acted as an inverse agonist to inhibit cAMP accumulation stimulated by the constitutively active GPR12.

Read the full article here:

https://www.ncbi.nlm.nih.gov/pubmed/28888984

Visit 

Dr. Dave Hepburn website: https://doctordavidhepburn.com

CBD May Inhibit the Pain Reducing Effects of THC

“Which is why it is important to know how cannabis acts as medicine. Don’t try to treat yourself with ditch weed, see a knowledgeable doctor. CBD acts as a NAM (negative allosteric modulator) to THC. This is sometimes beneficial (decreasespsycho active effects and allows THC to work longer) and sometimes possibly detrimental, as in this study.”

- Dr. David Hepburn

Abstract:

Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development.

The decrease in THC's antinociceptive effects after repeated CBD exposure may be due to CBD-induced inhibition of THC metabolism, and/or antagonism of THC effects that emerge with repeated CBD treatment.

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30238130

Visit 

Dr. Dave Hepburn website: https://doctordavidhepburn.com

CBD Reduces Cocaine Consumption

“CBD takes the lead cannabis role here as cocaine consumption and anxiety are reduced with repeated CBD treatment. CBD increased expression of cannabinoid receptors, BDNF expression, and neural cell proliferation in the hippocampus, all good things in helping to restructure neural pathways. The evidence for a role of CBD in treating substance abuse continues to point towards potential use in treatment centers.”

- Dr. David Hepburn

Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus.

Recent studies on the therapeutic effects of Cannabidiol (CBD) on drug abuse showed mixed results, especially with psychostimulant substances such as cocaine. To determine whether CBD can attenuate cocaine reinforcement, we assessed behavioural responses induced by cocaine in mice, using the behavioural sensitization, conditioned place preference and intravenous self-administration paradigms.

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30273593

Dr. David Hepburn website: https://doctordavidhepburn.com

CBD: Cheese Bacon Donuts

“With an increasing number of patients being prescribed CBD, it is often asked whether to take it on an empty stomach or with meals. PKPD studies show that taking it with a high fat meal increases the amount absorbed into the blood by over four times.”

-          Dr. David Hepburn

Abstract:

Background

A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose, and to examine the effect of food on CBD PK parameters.

Objective

This trial assessed the safety, tolerability and PK of CBD oral solution in healthy adult volunteers, as well as the effect of food on CBD PK parameters.

Methods

The study consisted of three arms: single ascending dose (1500, 3000, 4500 or 6000 mg CBD [n = 6 per group]/placebo [n = 8; 2 per CBD dose group]), multiple dose (750 or 1500 mg CBD [n = 9 per group]/placebo [n = 6; 3 per CBD dose group] twice daily), and food effect (1500 mg CBD single dose [n = 12]). All subjects completed all trial arms and were analyzed as planned.

Read full article here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223703/

Dr. David Hepburn website: https://doctordavidhepburn.com

New Research Indicates Benefit of Cannabis in Autism - Dr. David Hepburn

"And furthermore, dosages and CBD:THC ratios are starting to emerge. “Mothers” in many countries, recognizing that cannabis is helping their autistic children, have risked breaking the law and organized en masse to change laws. And now, significant attention is being directed towards using cannabis in this difficult spectrum. 1:20 THC:CBD at about 4 mg/kg CBD and 0.3mg/kg THC per day."

- Dr. David Hepburn.

Recommended by Dr. David Hepburn:

Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study.

Abstract

Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD.

To read the full article please visit:

https://www.ncbi.nlm.nih.gov/pubmed/30382443

Dr. Dave Hepburn website:https://doctordavidhepburn.com

CBD could reverse brain aging - Dr. Dave Hepburn

Article recommend by Dr. Dave Hepburn:

Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload

Abstract: 

Iron accumulation in the brain has been recognized as a common feature of both normal aging and neurodegenerative diseases. Cognitive dysfunction has been associated to iron excess in brain regions in humans. We have previously described that iron overload leads to severe memory deficits, including spatial, recognition, and emotional memory impairments in adult rats. In the present study we investigated the effects of neonatal iron overload on proteins involved in apoptotic pathways, such as Caspase 8, Caspase 9, Caspase 3, Cytochrome c, APAF1, and PARP in the hippocampus of adult rats, in an attempt to establish a causative role of iron excess on cell death in the nervous system, leading to memory dysfunction. Cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa, was examined as a potential drug to reverse iron-induced effects on the parameters analyzed. Male rats received vehicle or iron carbonyl (30 mg/kg) from the 12th to the 14th postnatal days and were treated with vehicle or CBD (10 mg/kg) for 14 days in adulthood. Iron increased Caspase 9, Cytochrome c, APAF1, Caspase 3 and cleaved PARP, without affecting cleaved Caspase 8 levels. CBD reversed iron-induced effects, recovering apoptotic proteins Caspase 9, APAF1, Caspase 3 and cleaved PARP to the levels found in controls. These results suggest that iron can trigger cell death pathways by inducing intrinsic apoptotic proteins. The reversal of iron-induced effects by CBD indicates that it has neuroprotective potential through its anti-apoptotic action.

“Studies like these are why we, at Plena, are inching closer to serious consideration of using CBD as a supplement for neuro-protection in the aging population. I continue to be excited by the volume of research that points to the safe, simple yet significant benefits of CBD in many different areas to help us age optimally. Everyone should have the chance to die young….at an old age." 

Dr. Dave Hepburn.

To read the full article please visit:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120904/

https://www.plena-global.com/

Dr. Dave Hepburn website:
doctordavidhepburn.com