Another GPR Affected by CBD

Thursday, 17 January 2019

“Add GPR12 to the growing list of orphaned receptors (no known natural ligands) with which cannabis interacts. GPR12 may be involved in metastatic (spreading) cancer. Interest continues to grow in the role of the many types of GP Receptors in disease process ranging from Parkinson’s Disease to Inflammatory bowel disease to cancers.”
- Dr. David Hepburn


GPR12 is a constitutively active, Gs protein-coupled receptor that currently has no confirmed endogenous ligands. 
GPR12 may be involved in physiological processes such as maintenance of oocyte meiotic arrest and brain development, as well as pathological conditions such as metastatic cancer.

In this document, the potential effects of various classes of cannabinoids on GPR12 were tested using a cAMP accumulation assay. 
Data demonstrate that cannabidiol (CBD), a major non-psychoactive phytocannabinoid, acted as an inverse agonist to inhibit cAMP accumulation stimulated by the constitutively active GPR12.

Read the full article here:


Dr. Dave Hepburn website:


Post a Comment

Related Posts Plugin for WordPress, Blogger...