Less Morphine Required When Cannabinoid Receptor Activated

Friday, 18 January 2019

“Many pain patients, with time, require increases of dose and/or frequency of the potentially deadly opiate morphine in order to obtain pain control. However, by activation of the CB2 receptor, tolerance and dependance of morphine was diminished.”
- Dr. David Hepburn


Morphine is widely used as an analgesic to treat moderate to severe pain, but chronic morphine use is associated with development of tolerance and dependence, which limits its analgesic efficacy.

A previous research has showed that non analgetic dose of a cannabinoid type 2 (CB2) receptor agonist reduced morphine tolerance in cancer pain. A previous study also showed the colocalization of CB2 and transient receptor potential vanilloid 1 (TRPV1) in human and rat dorsal root ganglia (DRG) sensory neurons.

Read the full article here:



Dr. Dave Hepburn website: https://doctordavidhepburn.com


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