“Many pain patients, with time, require increases of dose and/or frequency of the potentially deadly opiate morphine in order to obtain pain control. However, by activation of the CB2 receptor, tolerance and dependance of morphine was diminished.”
- Dr. David Hepburn
Abstract:
Morphine is widely used as an analgesic to treat moderate to severe pain, but chronic morphine use is associated with development of tolerance and dependence, which limits its analgesic efficacy.
A previous research has showed that non analgetic dose of a cannabinoid type 2 (CB2) receptor agonist reduced morphine tolerance in cancer pain. A previous study also showed the colocalization of CB2 and transient receptor potential vanilloid 1 (TRPV1) in human and rat dorsal root ganglia (DRG) sensory neurons.
Read the full article here:
https://www.ncbi.nlm.nih.gov/pubmed/28901432
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Dr. Dave Hepburn website: https://doctordavidhepburn.com
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