Early Life Stress and the ECS

“Levels of eCBs (AEA and 2AG) and the entire ECS, in fact, change in the hippocampus (memory) amygdala (fear) and PFC (executive) after early life stress. These continue in some of these regions into adulthood. Collectively, these data demonstrate that early life stress can alter the normative development (ontogeny) of the eCB system, resulting in a sustained deficit in function, particularly within the hippocampus, in adulthood.”

- Dr. David Hepburn 

Abstract:

Early-life stress modulates the development of cortico-limbic circuits and increases vulnerability to adult psychopathology. Given the important stress-buffering role of endocannabinoid (eCB) signaling, this is a comprehensive investigation of the developmental trajectory of the eCB system and the impact of exposure to early life stress induced by repeated maternal separation (MS; 3 h/day) from postnatal day 2 (PND2) to PND12.

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30496752

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Dr. David Hepburn website: https://doctordavidhepburn.com

Aging, Exercise and Cannabis

“The science of exercise has matured to a level of importance in the life cycle to reduce pain with aging and include new investigations on the ECS to explain its role in the well-being and improved quality of life in later years. A natural high as the number of  birthday candles get high.”

 - Dr. David Hepburn

Abstract:

Investigators have reported increases in circulating levels of eCB after exercise, with some eCB exerting analgesic effects from exercise. The focus of this review is to discuss evidence for the role of eCB and the complexities of the ECS in exercise and pain.

Some aspects presented are the production of ECB and activation of the cannabinoid receptors in the brain following exercise; eCB, pain, and physical activity; oxylipins; and joint pain.

As we age, an exercise in the form of play has evolved with the exploration of our body from walking to running, recreational, and competitive sports, to midlife physical activity focusing on maintaining fitness and healthy body weight.

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30290200

Dr. Dave Hepburn website: https://doctordavidhepburn.com