Endometrial Cancer Metastasis Responds to THC

“Add Uterine Cancer to the growing list of cancers that cannabinoids appear to affect. THC both inhibits cell migration (metastasis) of cancer cells and regulates tumor growth via both the CB1R and CB2R.”

- Dr. David Hepburn

Abstract:

Limited therapeutic interventions are clinically available for treating aggressive endometrial cancer (EC). Therefore, effective therapies are urgently required. Therefore, the present study investigated the role of ∆9-tetrahydrocannabinol (THC), which is reported to impact proliferative and migratory activities during impairment of cancer progression. In the present study, cell migration in response to THC was measured using transwell assays.

Read full article here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950514/

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Dr. Dave Hepburn website: https://doctordavidhepburn.com

Does Cannabis Significantly increase the risk of Traffic Accidents. No.

“The increased crash risk associated with THC-positive drivers in a large number of (meta-analysis) culpability studies show. Risk of being involved in or cause of traffic accident while using alcohol and many prescription drugs are not low.”

-       Dr. David Hepburn

Abstract:

Culpability studies, a common study design in the cannabis crash risk literature, typically report odds-ratios (OR) indicating the raised risks of a culpable accident. This parameter is of unclear policy relevance, and is frequently misinterpreted as an estimate of the increased crash risk, a practice that introduces a substantial "interpretational bias".

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30468948

VIsitDr. Dave Hepburn website: https://doctordavidhepburn.com

THCA May Protect Nerve Cells

“Another cannabinoid jumps into the fray and heads straight to thenucleus of the thenrve cell, working right at the DNA level. Could hold potential in dealing with the complicated neuro inflammatory related to neurodegeneration in so manytoughchronicconditions. (Alzheimer’s, Parkinson’s, ALS, MS, Huntingtonsetc).”

- Dr. David Hepburn

Abstract:

Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ9 -tetrahydrocannabinol have been extensively investigated, the bioactivity of Δ9 -tetahydrocannabinol acid (Δ9 -THCA) is largely unknown.

Δ9 -THCA shows potent neuroprotective activity, which is worth considering for the treatment of Huntington's disease and possibly other neurodegenerative and neuroinflammatory diseases.

Read the full article here:

https://www.ncbi.nlm.nih.gov/pubmed/28853159

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Dr. Dave Hepburn website: https://doctordavidhepburn.com

Inflammatory Bowel Responds to THCA

“With increased interest in the benefits of THCA which, unlike THC, is NON PSYCHOACTIVE, comes this study involving GPR55 receptors in the colon. The evidence of the role of cannabinoids in Crohn’s Disease and Ulcerative Colitis continues to point towards a therapeutic potential of cannabis for these difficult conditions.”

- Dr. David Hepburn

Abstract:

The anti-inflammatory activity of C. Sativa extracts was studied on three lines of epithelial cells and on colon tissue. C. sativa flowers were extracted with ethanol, enzyme-linked immunosorbent assay was used to determine the level of interleukin-8 in colon cells and tissue biopsies, chemical analysis was performed using high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance and gene expression was determined by quantitative real-time PCR.

Read the full article here:

https://www.liebertpub.com/doi/full/10.1089/can.2017.0027

Dr. Dave Hepburn website: https://doctordavidhepburn.com