Endometrial Cancer Metastasis Responds to THC

“Add Uterine Cancer to the growing list of cancers that cannabinoids appear to affect. THC both inhibits cell migration (metastasis) of cancer cells and regulates tumor growth via both the CB1R and CB2R.”

- Dr. David Hepburn

Abstract:

Limited therapeutic interventions are clinically available for treating aggressive endometrial cancer (EC). Therefore, effective therapies are urgently required. Therefore, the present study investigated the role of ∆9-tetrahydrocannabinol (THC), which is reported to impact proliferative and migratory activities during impairment of cancer progression. In the present study, cell migration in response to THC was measured using transwell assays.

Read full article here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950514/

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Dr. Dave Hepburn website: https://doctordavidhepburn.com

Why Women Don’t Forget

“Men appear to have 41% more CB1 receptors in the brain. Unfortunately for men of the male species, this is inversely related to working memory. (No memory of working). The sex difference in the ECS is becoming more interesting in explaining reactions and abilities in both.”

-    Dr. David Hepburn 

Abstract:

The endocannabinoid system (ECS) has a widespread neuron modulatory function in the central nervous system and is involved in important aspects of brain function including brain development, cortical rhythms, plasticity, reward, and stress sensitivity. 

Many of these effects are mediated via the cannabinoid CB1 receptor (CB1R) subtype. 

Animal studies convincingly have shown the interaction between the ECS and sex hormones, as well as a sex difference of higher brain CB1R in males. Human in vivo studies of sex difference has yielded discrete pant findings.

Read the full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30296558

Dr. David Hepburn website: https://doctordavidhepburn.com

Stimulation of Cannabinoid Receptor Inhibits Gastric Acid Secretion

“CB1R agonism (which is what THC is) inhibits powerful gastric acid secretion (a culprit in acid reflux and ulcers) while enhancing protective mucin release.”

-    Dr. David Hepburn

Summary:

Thecurrentstudyaimed to evaluate the role of cannabinoid receptors in the regulation of gastric acid secretion and oxidative stress in gastric mucosa. To fulfill this aim, gastric acid secretion stimulated with histamine (5 mg/kg, subcutaneous [SC]), 2-deoxy- d-glucose (D-G) (200 mg/kg, intravenous) or -carbachol (4 μg/kg, SC) in the 4-hour pylorus-ligated rats.

Read full article here:

https://www.ncbi.nlm.nih.gov/pubmed/30381869

Dr. David Hepburn website: https://doctordavidhepburn.com