Sexually Activity in Rats Increased by Cannabinoid 1 Receptor Activation

Monday, 5 November 2018

Article recommend by Dr. Dave Hepburn:

"Men and rats have been closely compared (primarily by women); hence this study is pertinent. The activation of CB1 receptors (the same receptors acted on by plant THC) by the endogenous cannabinoid, anandamide, transforms boring non copulating rats into sexually active animals." 
Dr. Dave Hepburn

Sexual interaction is essential for the transformation of non-copulating rats into sexually active animals by the endocannabinoid anandamide.


The endocannabinoid anandamide (AEA) transforms half of the population of previously non-copulating (NC) rats into sexually active animals in a long-lasting manner. The aim of this work was to explore the nature of this transformation.

We identified the dose range in which AEA induces mating behavior in previously NC rats, which evidenced a dose-based, biphasic profile for AEA to induce the transformation of NC rats. We demonstrate that the sexual interaction with a receptive female, involving at least an intromission, is essential for AEA to induce the transformation of NC rats.

This AEA-induced conversion is centrally mediated and involves the activation of CB1 receptors. Results indicate that the sexual impairment of this population of NC rats relies on their incapacity to initiate sexual activity and that an unidentified brain inhibitory influence on sexual behavior expression is removed by AEA treatment, allowing previously NC rats to show copulatory behavior in a long-lasting manner.

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