Article Recommended by Dr. David Hepburn:
Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
Abstract
Δ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid exposure in the adolescent period can also contribute to exacerbate behavioural deficits in adulthood.
Here we investigate the effects of THC treatment as well as the consequences of concomitant THC and stress exposure during adolescence in the extinction of fear memory in adult mice.
Adolescent mice treated with THC and exposed to stress exhibit impaired cued fear extinction in adulthood. However, no effect was observed in animals exposed to these two factors separately.
Notably, resistance to fear extinction was associated with decreased neuronal activity in the basolateral amygdala (BLA) and the infralimbic prefrontal cortex, suggesting a long-term dysregulation of the fear circuit.
"Yet another study underscoring why THC use in youth is of concern. Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood. As the youth brain is one that is “under construction”, THC should be used in this demographic under medical guidance…only."
Dr. Dave Hepburn
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